In this late-breaking poster session, our multidisciplinary team (acupuncture, nursing, psychology, integrative health) describes results of a usability study evaluating the use of a new mHealth app. EnergyPoints™ teaches and guides people living with cancer to implement daily acupressure to self-manage their symptoms at home. Using an integrated agile, user-centered design, 20 people with cancer participated in a think-aloud session onboarding and using the app to locate acupoints and then used the app to self-administer acupressure at home (twice daily for 1 week) while continuously wearing a fitness tracker synched with the app. The app measures self-report of symptoms daily and with weekly standardized PROMIS© measures. Findings support usability and guided improvements to the app based on user-experience. Research reported in this presentation was supported by the National Cancer Institute of the National Institutes of Health under Award Number R43CA261446 (Beck, SL, PI). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.