In this talk, we'll explore the dynamic partnership between a data scientist and a threat hunter as they join forces to elevate their company's machine learning (ML) powered detection and response capabilities. By blending threat intelligence with advanced ML techniques, they were able to create capabilities to uncover unknown threats across various data sources. Attendees will gain an understanding on how to bring ML into their detection strategy, practical applications of machine learning for threat detection, and understanding how to layer it with attacker operations and threat intelligence to enhance detection strategies, and see real-world examples of these concepts in action.