For 30 years, EUC has been about delivering apps and desktops to workers. That era is ending. AI is dissolving the application layer as workers are already delegating tasks to AI instead of opening apps, building workflows IT never sees, and treating AI as a coworker rather than a tool. This keynote explores what happens when the desktop stops being the center of work, when apps become optional middleware, and what EUC professionals should focus on next.