This presentation highlights the urgent need to implement sub-molecular-level information security (INFOSEC) as gene-editing technologies such as CRISPR/Cas9, CRISPR/Cas12a, and in vivo nanoparticles become more accessible and powerful. While these tools offer revolutionary medical benefits, they also introduce unprecedented biocybersecurity risks. From at-home DNA editing kits to remotely controlled nanoparticles, these innovations create potential vectors for cybercriminals to manipulate, corrupt, or extract genetic data. Such attacks could lead to harmful genetic mutations, physical or cognitive alterations, or even real-time remote interference with biological systems. As genetic data becomes digitized and integrated into the Internet of Things (IoT), the human body itself could become a vulnerable endpoint, exposing individuals to a new frontier of cyber threats.

Developing tailored INFOSEC strategies for biological systems is critical to address these emerging dangers. Traditional cybersecurity methods are insufficient to safeguard the integrity and confidentiality of genetic data, which now requires bio-specific protections. This includes secure data transmission, access controls on gene-editing tools, real-time monitoring, and defenses against unauthorized manipulation of medical nanotechnology. Without robust security measures, the misuse of gene-editing technology could lead to irreversible biological harm, breaches of privacy, and threats to human autonomy. As our biology becomes programmable, securing it against malicious manipulation must be prioritized to ensure both individual safety and the ethical evolution of biotechnology.