The COVID-19 pandemic has posed unprecedented challenges to businesses worldwide, including startups. This paper examines how global pandemics, such as COVID-19, affect the startup ecosystem, including their business models, funding, and strategies. We explore the lessons learned from the pandemic, the innovative approaches that startups adopted to navigate the crisis, and the lasting changes it has brought to the way startups operate. Through an analysis of real-world case studies and data, this paper offers insights into how startups can build resilience and adaptability to withstand future crises and uncertainties.