Our BoF panel features representatives of popular, highly specialized Linux distributions like Kairos, Flatcar, Eve, BottleRocket, Unikraft, SUSE MicroOS, and others. After a brief introduction we will open a discussion with the audience about the purpose, and limits, of special-purpose operating systems, on operational challenges, and on differences to general purpose operating systems. Discussions may include a wide variety of topics our audience is interested in discussing, e.g. opportunities to improve operations reliability and security, developing and operating cloud-native workloads, workload isolation, and trusted/measured boot.